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Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling
In response to virus infection, RIG-I-like receptors (RLRs) sense virus RNA and induce MAVS to form prion-like aggregates to further propagate antiviral signalling. Although monomeric MAVS recombinant protein can assemble into prion-like filaments spontaneously in vitro, endogenous MAVS in cells is...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5474743/ https://ncbi.nlm.nih.gov/pubmed/28607490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15676 |
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