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MAVS Forms Functional Prion-Like Aggregates To Activate and Propagate Antiviral Innate Immune Response
In response to viral infection, RIG-I–like RNA helicases bind to viral RNA and activate the mitochondrial protein MAVS, which in turn activates the transcription factors IRF3 and NF-κB to induce type-I interferons. We have previously shown that RIG-I binds to unanchored lysine-63 (K63) polyubiquitin...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3179916/ https://ncbi.nlm.nih.gov/pubmed/21782231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.06.041 |
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