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An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response
In response to virus infection, RIG-I senses viral RNA and activates the adaptor protein MAVS, which then forms prion-like filaments and stimulates a specific signalling pathway leading to type I interferon production to restrict virus proliferation. However, the mechanisms by which MAVS activity is...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4518314/ https://ncbi.nlm.nih.gov/pubmed/26183716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8811 |
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