Structural basis for the prion-like MAVS filaments in antiviral innate immunity

Mitochondrial antiviral signaling (MAVS) protein is required for innate immune responses against RNA viruses. In virus-infected cells MAVS forms prion-like aggregates to activate antiviral signaling cascades, but the underlying structural mechanism is unknown. Here we report cryo-electron microscopi...

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Detalles Bibliográficos
Autores principales: Xu, Hui, He, Xiaojing, Zheng, Hui, Huang, Lily J, Hou, Fajian, Yu, Zhiheng, de la Cruz, Michael Jason, Borkowski, Brian, Zhang, Xuewu, Chen, Zhijian J, Jiang, Qiu-Xing
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biophysics and Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932521/
https://ncbi.nlm.nih.gov/pubmed/24569476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01489
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