Upstream ORFs Prevent MAVS Spontaneous Aggregation and Regulate Innate Immune Homeostasis

The monomer-to-filament transition of MAVS is essential for the RIG-I/MDA5-mediated antiviral signaling. In quiescent cells, monomeric MAVS is under strict regulation for preventing its spontaneous aggregation, which would result in dysregulated interferon (IFN-α/β) production and autoimmune disease...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:iScience
Autori principali: Shi, Yuheng, Wu, Jing, Zhong, Tiansheng, Zhu, Wenting, She, Guolan, Tang, Hao, Du, Wei, Ye, Bang-Ce, Qi, Nan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190755/
https://ncbi.nlm.nih.gov/pubmed/32339989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101059
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi