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Upstream ORFs Prevent MAVS Spontaneous Aggregation and Regulate Innate Immune Homeostasis
The monomer-to-filament transition of MAVS is essential for the RIG-I/MDA5-mediated antiviral signaling. In quiescent cells, monomeric MAVS is under strict regulation for preventing its spontaneous aggregation, which would result in dysregulated interferon (IFN-α/β) production and autoimmune disease...
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| Izdano u: | iScience |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7190755/ https://ncbi.nlm.nih.gov/pubmed/32339989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101059 |
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