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Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling

Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large ligands, such as human echovirus 1. In this study, we show that the interaction bet...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Salmela, Maria, Jokinen, Johanna, Tiitta, Silja, Rappu, Pekka, Cheng, R. Holland, Heino, Jyrki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469853/
https://ncbi.nlm.nih.gov/pubmed/28611383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03640-w
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