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Proline hydroxylation in collagen supports integrin binding by two distinct mechanisms

Collagens are the most abundant extracellular matrix proteins in vertebrates and have a characteristic triple-helix structure. Hydroxylation of proline residues is critical for helix stability, and diminished prolyl hydroxylase activity causes wide-spread defects in connective tissues. Still, the ro...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Sipilä, Kalle H., Drushinin, Kati, Rappu, Pekka, Jokinen, Johanna, Salminen, Tiina A., Salo, Antti M., Käpylä, Jarmo, Myllyharju, Johanna, Heino, Jyrki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5961056/
https://ncbi.nlm.nih.gov/pubmed/29615493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002200
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