Novel α2β1 Integrin Inhibitors Reveal That Integrin Binding to Collagen under Shear Stress Conditions Does Not Require Receptor Preactivation

The interaction between α2β1 integrin (GPIa/IIa, VLA-2) and vascular collagen is one of the initiating events in thrombus formation. Here, we describe two structurally similar sulfonamide derivatives, BTT-3033 and BTT-3034, and show that, under static conditions, they have an almost identical effect...

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Detalhes bibliográficos
Main Authors: Nissinen, Liisa, Koivunen, Jarkko, Käpylä, Jarmo, Salmela, Maria, Nieminen, Jonna, Jokinen, Johanna, Sipilä, Kalle, Pihlavisto, Marjo, Pentikäinen, Olli T., Marjamäki, Anne, Heino, Jyrki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531784/
https://ncbi.nlm.nih.gov/pubmed/23132859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.309450
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