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Sulfonamide inhibitors of α2β1 integrin reveal the essential role of collagen receptors in in vivo models of inflammation

Small molecule inhibitors of α2β1 integrin, a major cellular collagen receptor, have been reported to inhibit platelet function, kidney injury, and angiogenesis. Since α2β1 integrin is abundantly expressed on various inflammation-associated cells, we tested whether recently developed α2β1 blocking s...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Nissinen, Liisa, Ojala, Marika, Langen, Barbara, Dost, Rita, Pihlavisto, Marjo, Käpylä, Jarmo, Marjamäki, Anne, Heino, Jyrki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4492762/
https://ncbi.nlm.nih.gov/pubmed/26171226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.146
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