Molecular mechanism of α2β1 integrin interaction with human echovirus 1

Conformational activation increases the affinity of integrins to their ligands. On ligand binding, further changes in integrin conformation elicit cellular signalling. Unlike any of the natural ligands of α2β1 integrin, human echovirus 1 (EV1) seemed to bind more avidly a ‘closed' than an activ...

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Autors principals: Jokinen, Johanna, White, Daniel J, Salmela, Maria, Huhtala, Mikko, Käpylä, Jarmo, Sipilä, Kalle, Puranen, J Santeri, Nissinen, Liisa, Kankaanpää, Pasi, Marjomäki, Varpu, Hyypiä, Timo, Johnson, Mark S, Heino, Jyrki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808374/
https://ncbi.nlm.nih.gov/pubmed/19927126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.326
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