Molecular mechanism of α2β1 integrin interaction with human echovirus 1

Conformational activation increases the affinity of integrins to their ligands. On ligand binding, further changes in integrin conformation elicit cellular signalling. Unlike any of the natural ligands of α2β1 integrin, human echovirus 1 (EV1) seemed to bind more avidly a ‘closed' than an activ...

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Detalhes bibliográficos
Main Authors: Jokinen, Johanna, White, Daniel J, Salmela, Maria, Huhtala, Mikko, Käpylä, Jarmo, Sipilä, Kalle, Puranen, J Santeri, Nissinen, Liisa, Kankaanpää, Pasi, Marjomäki, Varpu, Hyypiä, Timo, Johnson, Mark S, Heino, Jyrki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808374/
https://ncbi.nlm.nih.gov/pubmed/19927126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.326
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