Structure of Collagen Receptor Integrin α(1)I Domain Carrying the Activating Mutation E317A

We have analyzed the structure and function of the integrin α(1)I domain harboring a gain-of-function mutation E317A. To promote protein crystallization, a double variant with an additional C139S mutation was used. In cell adhesion assays, the E317A mutation promoted binding to collagen. Similarly,...

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Autores principales: Lahti, Matti, Bligt, Eva, Niskanen, Henri, Parkash, Vimal, Brandt, Anna-Maria, Jokinen, Johanna, Patrikainen, Pekka, Käpylä, Jarmo, Heino, Jyrki, Salminen, Tiina A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3234817/
https://ncbi.nlm.nih.gov/pubmed/22030389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.261909
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