Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells

Focal adhesion (FA) kinase (FAK) regulates cell survival and motility by transducing signals from membrane receptors. The C-terminal FA targeting (FAT) domain of FAK fulfils multiple functions, including recruitment to FAs through paxillin binding. Phosphorylation of FAT on Tyr(925) facilitates FA d...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kadaré, Gress, Gervasi, Nicolas, Brami-Cherrier, Karen, Blockus, Heike, El Messari, Said, Arold, Stefan T., Girault, Jean-Antoine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281750/
https://ncbi.nlm.nih.gov/pubmed/25391654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593632
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