Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells

Focal adhesion (FA) kinase (FAK) regulates cell survival and motility by transducing signals from membrane receptors. The C-terminal FA targeting (FAT) domain of FAK fulfils multiple functions, including recruitment to FAs through paxillin binding. Phosphorylation of FAT on Tyr(925) facilitates FA d...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Kadaré, Gress, Gervasi, Nicolas, Brami-Cherrier, Karen, Blockus, Heike, El Messari, Said, Arold, Stefan T., Girault, Jean-Antoine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2015
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281750/
https://ncbi.nlm.nih.gov/pubmed/25391654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593632
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