Conformational Dynamics of the Focal Adhesion Targeting Domain Control Specific Functions of Focal Adhesion Kinase in Cells

Focal adhesion (FA) kinase (FAK) regulates cell survival and motility by transducing signals from membrane receptors. The C-terminal FA targeting (FAT) domain of FAK fulfils multiple functions, including recruitment to FAs through paxillin binding. Phosphorylation of FAT on Tyr(925) facilitates FA d...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Kadaré, Gress, Gervasi, Nicolas, Brami-Cherrier, Karen, Blockus, Heike, El Messari, Said, Arold, Stefan T., Girault, Jean-Antoine
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281750/
https://ncbi.nlm.nih.gov/pubmed/25391654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593632
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