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Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages
Pyroptosis is a lytic form of programmed cell death mediated by the inflammatory caspases-1, -4, and -5. We recently discovered that small molecule inhibitors of the serine peptidases DPP8 and DPP9 (DPP8/9) induce pro-caspase-1 dependent pyroptosis in monocytes and macrophages. Notably, DPP8/9 inhib...
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| Publicado no: | Cell Chem Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467448/ https://ncbi.nlm.nih.gov/pubmed/28392147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.03.009 |
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