Bidirectional Crosstalk between C5a Receptors and the NLRP3 Inflammasome in Macrophages and Monocytes

C5a is an inflammatory mediator generated by complement activation that positively regulates various arms of immune defense, including Toll-like receptor 4 (TLR4) signaling. The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome is activated by pathogen products and cellular/ti...

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Bibliographic Details
Published in:Mediators Inflamm
Main Authors: Haggadone, Mikel D., Grailer, Jamison J., Fattahi, Fatemeh, Zetoune, Firas S., Ward, Peter A.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921141/
https://ncbi.nlm.nih.gov/pubmed/27382187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1340156
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