Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to anti-malarial agent dihydroartemisinin

The oxidative pentose phosphate pathway (PPP) is crucial for cancer cell metabolism and tumor growth. We recently reported that targeting a key oxidative PPP enzyme, 6-phosphogluconate dehydrogenase (6PGD), using our novel small molecule 6PGD inhibitors Physcion and its derivative S3, shows anti-can...

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Publicado en:Oncogene
Main Authors: Elf, Shannon, Lin, Ruiting, Xia, Siyuan, Pan, Yaozhu, Shan, Changliang, Wu, Shaoxiong, Lonial, Sagar, Gaddh, Manila, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Boggon, Titus J., Fan, Jun, Chen, Jing
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464402/
https://ncbi.nlm.nih.gov/pubmed/27270429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.196
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