Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth

Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) regulates pyruvate dehydrogenase complex (PDC) by acetylating pyruvate dehydrogenase (PDH) and PDH phosphatase. How ACAT1 is “hijacked” to contribute to the Warburg effect in human cancer remains unclear. We found that active, tetrameric ACAT1 is...

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I publikationen:Mol Cell
Huvudupphovsmän: Fan, Jun, Lin, Ruiting, Xia, Siyuan, Chen, Dong, Elf, Shannon E., Liu, Shuangping, Pan, Yaozhu, Xu, Haidong, Qian, Zhiyu, Wang, Mei, Shan, Changliang, Zhou, Lu, Lei, Qun-Ying, Li, Yuancheng, Mao, Hui, Lee, Benjamin H., Sudderth, Jessica, DeBerardinis, Ralph J., Zhang, Guojing, Owonikoko, Taofeek, Gaddh, Manila, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Kang, Sumin, Doetsch, Paul W., Lonial, Sagar, Boggon, Titus J., Curran, Walter J., Chen, Jing
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135630/
https://ncbi.nlm.nih.gov/pubmed/27867011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.10.014
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