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Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth
Mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) regulates pyruvate dehydrogenase complex (PDC) by acetylating pyruvate dehydrogenase (PDH) and PDH phosphatase. How ACAT1 is “hijacked” to contribute to the Warburg effect in human cancer remains unclear. We found that active, tetrameric ACAT1 is...
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| Veröffentlicht in: | Mol Cell |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5135630/ https://ncbi.nlm.nih.gov/pubmed/27867011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.10.014 |
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