γ-6-phosphogluconolactone, a byproduct of the oxidative pentose phosphate pathway, contributes to AMPK activation through inhibition of PP2A

The oxidative pentose phosphate pathway (oxiPPP) contributes to cell metabolism through not only the production of metabolic intermediates and reductive NADPH, but also inhibition of LKB1-AMPK signaling by ribulose-5-phosphate (Ru-5-P), the product of the third oxiPPP enzyme 6-phosphogluconate dehyd...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Gao, Xue, Zhao, Liang, Liu, Shuangping, Li, Yuancheng, Xia, Siyuan, Chen, Dong, Wang, Mei, Wu, Shaoxiong, Dai, Qing, Vu, Hieu, Zacharias, Lauren, DeBerardinis, Ralph, Lim, Esther, Metallo, Christian, Boggon, Titus J., Lonial, Sagar, Lin, Ruiting, Mao, Hui, Pan, Yaozhu, Shan, Changliang, Chen, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6925637/
https://ncbi.nlm.nih.gov/pubmed/31586547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.007
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