6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling

The oxidative pentose phosphate pathway (PPP) contributes to tumor growth, but the precise contribution of 6-phosphogluconate dehydrogenase (6PGD), the third enzyme in this pathway, to tumorigenesis remains unclear. We found that suppression of 6PGD decreased lipogenesis and RNA biosynthesis and ele...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Lin, Ruiting, Elf, Shannon, Shan, Changliang, Kang, Hee-Bum, Ji, Quanjiang, Zhou, Lu, Hitosugi, Taro, Zhang, Liang, Zhang, Shuai, Ho Seo, Jae, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Sudderth, Jessica, Jiang, Lei, Mitsche, Matthew, DeBerardinis, Ralph J., Wu, Shaoxiong, Li, Yuancheng, Mao, Hui, Chen, Peng R., Wang, Dongsheng, Chen, Georgia Zhuo, Hurwitz, Selwyn J., Lonial, Sagar, Khoury, Hanna J., Arellano, Martha L., Khuri, Fadlo R., Lee, Benjamin H., Lei, Qunying, Brat, Daniel J., Ye, Keqiang, Boggon, Titus J., He, Chuan, Kang, Sumin, Fan, Jun, Chen, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628560/
https://ncbi.nlm.nih.gov/pubmed/26479318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3255
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados