Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth

Although the oxidative pentose phosphate pathway is important for tumor growth, how 6-phosphogluconate dehydrogenase (6PGD) in this pathway is upregulated in human cancers is unknown. We found that 6PGD is commonly activated in EGF-stimulated cells and human cancer cells by lysine acetylation. Acety...

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Autors principals: Shan, Changliang, Elf, Shannon, Ji, Quanjiang, Kang, Hee-Bum, Zhou, Lu, Hitosugi, Taro, Jin, Lingtao, Lin, Ruiting, Zhang, Liang, Seo, Jae Ho, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Sudderth, Jessica, Jiang, Lei, DeBerardinis, Ralph J., Wu, Shaoxiong, Li, Yuancheng, Mao, Hui, Chen, Peng, Wang, Dongsheng, Chen, Georgia Zhuo, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Brat, Daniel J., Ye, Keqiang, Boggon, Titus J., He, Chuan, Kang, Sumin, Fan, Jun, Chen, Jing
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142084/
https://ncbi.nlm.nih.gov/pubmed/25042803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.06.020
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