Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models

BACKGROUND: Signaling through mTOR and somatostatin pathway is implicated in thyroid cancer development. METHOD: We evaluated everolimus, an mTOR inhibitor and pasireotide, a multi receptor somatostatin analogue as potential therapy of thyroid cancer focusing on the in vitro and in vivo efficacy, as...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Owonikoko, Taofeek K., Zhang, Guojing, Lallani, Shenila B., Chen, Zhengjia, Martinson, Deborah E., Khuri, Fadlo R., Lonial, Sagar, Marcus, Adam, Sun, Shi-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390992/
https://ncbi.nlm.nih.gov/pubmed/30807575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206309
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