Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids

Colorectal cancer is driven by cooperating oncogenic mutations. In this study, we use organotypic cultures derived from transgenic mice inducibly expressing oncogenic β-catenin and/or PIK3CA(H1047R) to follow sequential changes in cancer-related signaling networks, intestinal cell metabolism, and ph...

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Publicat a:J Cell Biol
Autors principals: Riemer, Pamela, Rydenfelt, Mattias, Marks, Matthias, van Eunen, Karen, Thedieck, Kathrin, Herrmann, Bernhard G., Blüthgen, Nils, Sers, Christine, Morkel, Markus
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461020/
https://ncbi.nlm.nih.gov/pubmed/28442534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610058
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