Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids

Colorectal cancer is driven by cooperating oncogenic mutations. In this study, we use organotypic cultures derived from transgenic mice inducibly expressing oncogenic β-catenin and/or PIK3CA(H1047R) to follow sequential changes in cancer-related signaling networks, intestinal cell metabolism, and ph...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Riemer, Pamela, Rydenfelt, Mattias, Marks, Matthias, van Eunen, Karen, Thedieck, Kathrin, Herrmann, Bernhard G., Blüthgen, Nils, Sers, Christine, Morkel, Markus
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2017
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461020/
https://ncbi.nlm.nih.gov/pubmed/28442534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610058
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak