Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids

Colorectal cancer is driven by cooperating oncogenic mutations. In this study, we use organotypic cultures derived from transgenic mice inducibly expressing oncogenic β-catenin and/or PIK3CA(H1047R) to follow sequential changes in cancer-related signaling networks, intestinal cell metabolism, and ph...

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Bibliografische gegevens
Gepubliceerd in:J Cell Biol
Hoofdauteurs: Riemer, Pamela, Rydenfelt, Mattias, Marks, Matthias, van Eunen, Karen, Thedieck, Kathrin, Herrmann, Bernhard G., Blüthgen, Nils, Sers, Christine, Morkel, Markus
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2017
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461020/
https://ncbi.nlm.nih.gov/pubmed/28442534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610058
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