Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids

Colorectal cancer is driven by cooperating oncogenic mutations. In this study, we use organotypic cultures derived from transgenic mice inducibly expressing oncogenic β-catenin and/or PIK3CA(H1047R) to follow sequential changes in cancer-related signaling networks, intestinal cell metabolism, and ph...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Riemer, Pamela, Rydenfelt, Mattias, Marks, Matthias, van Eunen, Karen, Thedieck, Kathrin, Herrmann, Bernhard G., Blüthgen, Nils, Sers, Christine, Morkel, Markus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2017
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5461020/
https://ncbi.nlm.nih.gov/pubmed/28442534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201610058
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