Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

Oncogenic mutations in KRAS or BRAF are frequent in colorectal cancer and activate the ERK kinase. Here, we find graded ERK phosphorylation correlating with cell differentiation in patient-derived colorectal cancer organoids with and without KRAS mutations. Using reporters, single cell transcriptomi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Brandt, Raphael, Sell, Thomas, Lüthen, Mareen, Uhlitz, Florian, Klinger, Bertram, Riemer, Pamela, Giesecke-Thiel, Claudia, Schulze, Silvia, El-Shimy, Ismail Amr, Kunkel, Desiree, Fauler, Beatrix, Mielke, Thorsten, Mages, Norbert, Herrmann, Bernhard G., Sers, Christine, Blüthgen, Nils, Morkel, Markus
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606648/
https://ncbi.nlm.nih.gov/pubmed/31266962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10954-y
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak