Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS

RAS mutations are highly relevant for progression and therapy response of human tumours, but the genetic network that ultimately executes the oncogenic effects is poorly understood. Here, we used a reverse-engineering approach in an ovarian cancer model to reconstruct KRAS oncogene-dependent cytopla...

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Bibliographische Detailangaben
Hauptverfasser: Stelniec-Klotz, Iwona, Legewie, Stefan, Tchernitsa, Oleg, Witzel, Franziska, Klinger, Bertram, Sers, Christine, Herzel, Hanspeter, Blüthgen, Nils, Schäfer, Reinhold
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421447/
https://ncbi.nlm.nih.gov/pubmed/22864383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2012.32
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