Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS

RAS mutations are highly relevant for progression and therapy response of human tumours, but the genetic network that ultimately executes the oncogenic effects is poorly understood. Here, we used a reverse-engineering approach in an ovarian cancer model to reconstruct KRAS oncogene-dependent cytopla...

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Main Authors: Stelniec-Klotz, Iwona, Legewie, Stefan, Tchernitsa, Oleg, Witzel, Franziska, Klinger, Bertram, Sers, Christine, Herzel, Hanspeter, Blüthgen, Nils, Schäfer, Reinhold
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421447/
https://ncbi.nlm.nih.gov/pubmed/22864383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2012.32
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