Reduced replication origin licensing selectively kills KRAS-mutant colorectal cancer cells via mitotic catastrophe

To unravel vulnerabilities of KRAS-mutant CRC cells, a shRNA-based screen specifically inhibiting MAPK pathway components and targets was performed in CaCo2 cells harboring conditional oncogenic KRAS(G12V). The custom-designed shRNA library comprised 121 selected genes, which were previously identif...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Gastl, Bastian, Klotz-Noack, Kathleen, Klinger, Bertram, Ispasanie, Sylvia, Salib, Krenoula Hani Fouad, Zuber, Johannes, Mamlouk, Soulafa, Bublitz, Natalie, Blüthgen, Nils, Horst, David, Morkel, Markus, Schäfer, Reinhold, Sers, Christine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7330027/
https://ncbi.nlm.nih.gov/pubmed/32612138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2704-9
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