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Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance

Colorectal cancer (CRC) is characterized by recurrent mutations deregulating key cell signaling cascades and providing the cancer cells with novel functional traits. Among the most frequent mutations in CRC are gain-of-function missense mutations in KRAS and BRAF. Oncogenic activation of KRAS and BR...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Morkel, Markus, Riemer, Pamela, Bläker, Hendrik, Sers, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673229/
https://ncbi.nlm.nih.gov/pubmed/26299805
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