Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer

Metabolic reprogramming, in which altered utilization of glucose and glutamine supports rapid growth, is a hallmark of most cancers. Mutations in the oncogenes KRAS and BRAF drive metabolic reprogramming through enhanced glucose uptake, but the broader impact of these mutations on pathways of carbon...

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Bibliografiske detaljer
Udgivet i:Mol Cell Proteomics
Main Authors: Hutton, Josiah E., Wang, Xiaojing, Zimmerman, Lisa J., Slebos, Robbert J. C., Trenary, Irina A., Young, Jamey D., Li, Ming, Liebler, Daniel C.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013308/
https://ncbi.nlm.nih.gov/pubmed/27340238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.058925
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