Shp2 Deletion in Hepatocytes Suppresses Hepatocarcinogenesis Driven by Oncogenic β-Catenin, PIK3CA and MET

BACKGROUND AND AIMS: Shp2 is an SH2-tyrosine phosphatase acting downstream of receptor tyrosine kinases (RTKs). Most recent data demonstrated a liver tumor-suppressing role for Shp2, as ablating Shp2 in hepatocytes aggravated hepatocellular carcinoma (HCC) induced by chemical carcinogen or Pten loss...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: Liu, Jacey J., Li, Yanjie, Chen, Wendy S., Liang, Yan, Wang, Gaowei, Zong, Min, Kaneko, Kota, Xu, Ruiyun, Karin, Michael, Feng, Gen-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008184/
https://ncbi.nlm.nih.gov/pubmed/29505847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2018.02.014
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