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Fidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus

Using poliovirus (PV) and its RNA-dependent RNA polymerase (RdRp) as our primary model system, we have advanced knowledge fundamental to the chemistry and fidelity of nucleotide addition by nucleic acid polymerase. Two fidelity checkpoints exist prior to nucleotide addition. The first toggles the en...

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Bibliografski detalji
Izdano u:Enzymes
Glavni autori: Cameron, C.E., Moustafa, I.M., Arnold, J.J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458529/
https://ncbi.nlm.nih.gov/pubmed/27241934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.enz.2016.02.002
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