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What Is the Role of Motif D in the Nucleotide Incorporation Catalyzed by the RNA-dependent RNA Polymerase from Poliovirus?

Poliovirus (PV) is a well-characterized RNA virus, and the RNA-dependent RNA polymerase (RdRp) from PV (3D(pol)) has been widely employed as an important model for understanding the structure-function relationships of RNA and DNA polymerases. Many experimental studies of the kinetics of nucleotide i...

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Bibliographic Details
Main Authors: Shen, Hujun, Sun, Hui, Li, Guohui
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531290/
https://ncbi.nlm.nih.gov/pubmed/23300428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002851
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