Vaccine-derived Mutation in Motif D of Poliovirus RNA-dependent RNA Polymerase Lowers Nucleotide Incorporation Fidelity

All viral RNA-dependent RNA polymerases (RdRps) have a conserved structural element termed motif D. Studies of the RdRp from poliovirus (PV) have shown that a conformational change of motif D leads to efficient and faithful nucleotide addition by bringing Lys-359 into the active site where it serves...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Xinran, Yang, Xiaorong, Lee, Cheri A., Moustafa, Ibrahim M., Smidansky, Eric D., Lum, David, Arnold, Jamie J., Cameron, Craig E., Boehr, David D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820909/
https://ncbi.nlm.nih.gov/pubmed/24085299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484428
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