Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases

The nucleotide incorporation fidelity of the viral RNA-dependent RNA polymerase (RdRp) is important for maintaining functional genetic information but, at the same time, is also important for generating sufficient genetic diversity to escape the bottlenecks of the host's antiviral response. We...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yang, Xiaorong, Liu, Xinran, Musser, Derek M., Moustafa, Ibrahim M., Arnold, Jamie J., Cameron, Craig E., Boehr, David D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339763/
https://ncbi.nlm.nih.gov/pubmed/28100782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750638
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