Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases

The nucleotide incorporation fidelity of the viral RNA-dependent RNA polymerase (RdRp) is important for maintaining functional genetic information but, at the same time, is also important for generating sufficient genetic diversity to escape the bottlenecks of the host's antiviral response. We...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yang, Xiaorong, Liu, Xinran, Musser, Derek M., Moustafa, Ibrahim M., Arnold, Jamie J., Cameron, Craig E., Boehr, David D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339763/
https://ncbi.nlm.nih.gov/pubmed/28100782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750638
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