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Triphosphate Reorientation of the Incoming Nucleotide as a Fidelity Checkpoint in Viral RNA-dependent RNA Polymerases

The nucleotide incorporation fidelity of the viral RNA-dependent RNA polymerase (RdRp) is important for maintaining functional genetic information but, at the same time, is also important for generating sufficient genetic diversity to escape the bottlenecks of the host's antiviral response. We...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Yang, Xiaorong, Liu, Xinran, Musser, Derek M., Moustafa, Ibrahim M., Arnold, Jamie J., Cameron, Craig E., Boehr, David D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339763/
https://ncbi.nlm.nih.gov/pubmed/28100782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750638
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