Rational control of poliovirus RNA-dependent RNA polymerase fidelity by modulating motif D loop conformational dynamics

The conserved structural motif D is an important determinant of the speed and fidelity of viral RNA-dependent RNA polymerases (RdRps). Structural and computational studies have suggested that conformational changes in the motif-D loop that help to reposition the catalytic lysine represent critical s...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Shi, Jingjing, Perryman, Jacob M., Yang, Xiaorong, Liu, Xinran, Musser, Derek M., Boehr, Alyson K., Moustafa, Ibrahim M., Arnold, Jamie J., Cameron, Craig E., Boehr, David D.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767926/
https://ncbi.nlm.nih.gov/pubmed/31424194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00497
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