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Rational control of poliovirus RNA-dependent RNA polymerase fidelity by modulating motif D loop conformational dynamics
The conserved structural motif D is an important determinant of the speed and fidelity of viral RNA-dependent RNA polymerases (RdRps). Structural and computational studies have suggested that conformational changes in the motif-D loop that help to reposition the catalytic lysine represent critical s...
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| Publicado no: | Biochemistry |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6767926/ https://ncbi.nlm.nih.gov/pubmed/31424194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00497 |
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