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Rational control of poliovirus RNA-dependent RNA polymerase fidelity by modulating motif D loop conformational dynamics

The conserved structural motif D is an important determinant of the speed and fidelity of viral RNA-dependent RNA polymerases (RdRps). Structural and computational studies have suggested that conformational changes in the motif-D loop that help to reposition the catalytic lysine represent critical s...

詳細記述

保存先:
書誌詳細
出版年:Biochemistry
主要な著者: Shi, Jingjing, Perryman, Jacob M., Yang, Xiaorong, Liu, Xinran, Musser, Derek M., Boehr, Alyson K., Moustafa, Ibrahim M., Arnold, Jamie J., Cameron, Craig E., Boehr, David D.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767926/
https://ncbi.nlm.nih.gov/pubmed/31424194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00497
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