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Fidelity of Nucleotide Incorporation by the RNA-Dependent RNA Polymerase from Poliovirus

Using poliovirus (PV) and its RNA-dependent RNA polymerase (RdRp) as our primary model system, we have advanced knowledge fundamental to the chemistry and fidelity of nucleotide addition by nucleic acid polymerase. Two fidelity checkpoints exist prior to nucleotide addition. The first toggles the en...

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Detalhes bibliográficos
Publicado no:Enzymes
Main Authors: Cameron, C.E., Moustafa, I.M., Arnold, J.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458529/
https://ncbi.nlm.nih.gov/pubmed/27241934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.enz.2016.02.002
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