DNA‐induced unfolding of the thyroid hormone receptor α A/B domain through allostery

The A/B domains of nuclear receptors such as thyroid receptor α (TRα) are considered to be conformationally flexible and can potentially adopt multiple structural conformations. We used intrinsic tryptophan fluorescence quenching and circular dichroism spectroscopy to characterize the unfolding of t...

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Bibliographic Details
Published in:FEBS Open Bio
Main Authors: Fernandez, Elias J., Gahlot, Vandna, Rodriguez, Celeste, Amburn, Jacob
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458466/
https://ncbi.nlm.nih.gov/pubmed/28593140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12229
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