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Allostery through DNA drives phenotype switching

Allostery is a pervasive principle to regulate protein function. Growing evidence suggests that also DNA is capable of transmitting allosteric signals. Yet, whether and how DNA-mediated allostery plays a regulatory role in gene expression remained unclear. Here, we show that DNA indeed transmits all...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Rosenblum, Gabriel, Elad, Nadav, Rozenberg, Haim, Wiggers, Felix, Jungwirth, Jakub, Hofmann, Hagen
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170675/
https://ncbi.nlm.nih.gov/pubmed/34016970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23148-2
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