Chromosome instability drives phenotypic switching to metastasis

Chromosome instability (CIN) is the most striking feature of human cancers. However, how CIN drives tumor progression to metastasis remains elusive. Here we studied the role of chromosome content changes in generating the phenotypic dynamics that are required for metastasis. We isolated epithelial a...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Gao, ChongFeng, Su, Yanli, Koeman, Julie, Haak, Elizabeth, Dykema, Karl, Essenberg, Curt, Hudson, Eric, Petillo, David, Khoo, Sok Kean, Vande Woude, George F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187712/
https://ncbi.nlm.nih.gov/pubmed/27930335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1618215113
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