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Discrimination of DNA response elements for thyroid hormone and estrogen is dependent on dimerization of receptor DNA binding domains.

We and others have previously shown that a two-amino acid substitution in the base of the first zinc finger of the glucocorticoid receptor DNA binding domain (DBD) is sufficient to alter the receptor's target DNA from a glucocorticoid response element (GRE) to an estrogen response element (ERE). Act...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hirst, M A, Hinck, L, Danielsen, M, Ringold, G M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49325/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1608965/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.12.5527
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