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Discrimination of DNA response elements for thyroid hormone and estrogen is dependent on dimerization of receptor DNA binding domains.

We and others have previously shown that a two-amino acid substitution in the base of the first zinc finger of the glucocorticoid receptor DNA binding domain (DBD) is sufficient to alter the receptor's target DNA from a glucocorticoid response element (GRE) to an estrogen response element (ERE)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hirst, M A, Hinck, L, Danielsen, M, Ringold, G M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC49325/
https://ncbi.nlm.nih.gov/pubmed/1608965
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