Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

In model organisms, comprehensive loss-of-function genetic screens have facilitated the identification of pathway components and regulatory nodes. However, although we now have tools that allow the systematic manipulation of genes in mammalian cells, studies using genome scale tools have focused alm...

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Bibliografski detalji
Izdano u:Cell Syst
Glavni autori: Rosenbluh, Joseph, Mercer, Johnathan, Shrestha, Yashaswi, Oliver, Rachel, Tamayo, Pablo, Doench, John G., Tirosh, Itay, Piccioni, Federica, Hartenian, Ella, Horn, Heiko, Fagbami, Lola, Root, David E., Jaffe, Jacob, Lage, Kasper, Boehm, Jesse S., Hahn, William C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455996/
https://ncbi.nlm.nih.gov/pubmed/27684187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.09.001
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