Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers

3q26 is frequently amplified in several cancer types with a common amplified region containing 20 genes. To identify cancer driver genes in this region, we interrogated the function of each of these genes by loss- and gain-of-function genetic screens. Specifically, we found that TLOC1 (SEC62) was se...

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Main Authors: Hagerstrand, Daniel, Tong, Alexander, Schumacher, Steven E., Ilic, Nina, Shen, Rhine R., Cheung, Hiu Wing, Vazquez, Francisca, Shrestha, Yashaswi, Kim, So Young, Giacomelli, Andrew O., Rosenbluh, Joseph, Schinzel, Anna C., Spardy, Nicole A., Barbie, David A., Mermel, Craig H., Weir, Barbara A., Garraway, Levi A., Tamayo, Pablo, Mesirov, Jill P., Beroukhim, Rameen, Hahn, William C.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770815/
https://ncbi.nlm.nih.gov/pubmed/23764425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0592
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