Systematic functional interrogation of rare cancer variants identifies oncogenic alleles

Cancer genome characterization efforts now provide an initial view of the somatic alterations in primary tumors. However, most point mutations occur at low frequency. and the function of these alleles remain undefined. We have developed a scalable systematic approach to interrogate the function of c...

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Foilsithe in:Cancer Discov
Main Authors: Kim, Eejung, Ilic, Nina, Shrestha, Yashaswi, Zou, Lihua, Kamburov, Atanas, Zhu, Cong, Yang, Xiaoping, Lubonja, Rakela, Tran, Nancy, Nguyen, Cindy, Lawrence, Michael S., Piccioni, Federica, Bagul, Mukta, Doench, John G., Chouinard, Candace R., Wu, Xiaoyun, Hogstrom, Larson, Natoli, Ted, Tamayo, Pablo, Horn, Heiko, Corsello, Steven M., Lage, Kasper, Root, David E., Subramanian, Aravind, Golub, Todd R., Getz, Gad, Boehm, Jesse S., Hahn, William C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930723/
https://ncbi.nlm.nih.gov/pubmed/27147599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0160
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