Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

In model organisms, comprehensive loss-of-function genetic screens have facilitated the identification of pathway components and regulatory nodes. However, although we now have tools that allow the systematic manipulation of genes in mammalian cells, studies using genome scale tools have focused alm...

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Pubblicato in:Cell Syst
Autori principali: Rosenbluh, Joseph, Mercer, Johnathan, Shrestha, Yashaswi, Oliver, Rachel, Tamayo, Pablo, Doench, John G., Tirosh, Itay, Piccioni, Federica, Hartenian, Ella, Horn, Heiko, Fagbami, Lola, Root, David E., Jaffe, Jacob, Lage, Kasper, Boehm, Jesse S., Hahn, William C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455996/
https://ncbi.nlm.nih.gov/pubmed/27684187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.09.001
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