Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

In model organisms, comprehensive loss-of-function genetic screens have facilitated the identification of pathway components and regulatory nodes. However, although we now have tools that allow the systematic manipulation of genes in mammalian cells, studies using genome scale tools have focused alm...

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發表在:Cell Syst
Main Authors: Rosenbluh, Joseph, Mercer, Johnathan, Shrestha, Yashaswi, Oliver, Rachel, Tamayo, Pablo, Doench, John G., Tirosh, Itay, Piccioni, Federica, Hartenian, Ella, Horn, Heiko, Fagbami, Lola, Root, David E., Jaffe, Jacob, Lage, Kasper, Boehm, Jesse S., Hahn, William C.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455996/
https://ncbi.nlm.nih.gov/pubmed/27684187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.09.001
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