Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers

In model organisms, comprehensive loss-of-function genetic screens have facilitated the identification of pathway components and regulatory nodes. However, although we now have tools that allow the systematic manipulation of genes in mammalian cells, studies using genome scale tools have focused alm...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Rosenbluh, Joseph, Mercer, Johnathan, Shrestha, Yashaswi, Oliver, Rachel, Tamayo, Pablo, Doench, John G., Tirosh, Itay, Piccioni, Federica, Hartenian, Ella, Horn, Heiko, Fagbami, Lola, Root, David E., Jaffe, Jacob, Lage, Kasper, Boehm, Jesse S., Hahn, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5455996/
https://ncbi.nlm.nih.gov/pubmed/27684187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.09.001
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