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Discriminatory suppression of homologous recombination by p53

Homologous recombination (HR) is used in vertebrate somatic cells for essential, RAD51-dependent, repair of DNA double-strand-breaks (DSBs), but inappropriate HR can cause genome instability. A transcriptional transactivation-independent role for p53 in suppressing HR has been established, but is no...

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Detalhes bibliográficos
Main Authors: Yun, Sheng, Lie-A-Cheong, Chadwick, Porter, Andrew C. G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC545454/
https://ncbi.nlm.nih.gov/pubmed/15601996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh986
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